Dulutvir Sodium/ Dolutegravir Sodium API

Name	Dulutvir Sodium/ Dolutegravir Sodium
Chinese name	度鲁特韦钠/多替拉韦钠
Cas Number	1051375-19-9
Source	India
Qualifications	USDMF/-/-/-/-

Dulutvir free acid is a new anti-AIDS drug developed by the British pharmaceutical giant GlaxoSmithKline (GSK) and Japan's Shionogi Pharmaceutical Company (Shionogi). On August 12, 2013, the US Food and Drug Administration ( FDA) approved the listing. Dulutvir sodium is a second-generation HIV-1 integrase chain transfer inhibitor. It has been shown that dulutvir sodium can effectively inhibit HIV replication in cells infected with the inactivated PHIV lentiviral vector. According to the results of phase III clinical trials, after 48 weeks of treatment with dulutvir and two other old AIDS drugs, 88% of the virus in the patient's body was successfully suppressed, while taking Gilead Sciences' three-in-one oral drug Atripla 81%, Dulutwei slightly better. The researchers said that in the comparison trial, due to the side effects of the drug, 10% of the patients eventually stopped taking the Atripla drug, but only 2% of the patients stopped taking the dulutvir drug. This shows the safety of dulutvir. higher. The latest research points out that a treatment plan based on the new anti-HIV drug dulutvir can safely and quickly inhibit HIV in pregnant women, reducing the risk of mother-to-child transmission in women at high risk of AIDS during pregnancy and breastfeeding. The World Health Organization recommends that countries use dulutvir as the drug of choice for the treatment of HIV, which is more effective and tolerable than other drugs. Rutway's sales in 2016 were US$953 million, an increase of 62% compared to 2015. Analysts predict that Dulutvir is expected to become a blockbuster drug with annual sales of billions of dollars, and at the same time it will become a strong competitor of Gilead Biology's world's best-selling HIV compound drug Atripla.

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