Verapamil API

Name	Verapamil
Chinese name	维拉帕米
Cas Number	52-53-9
Source	India
Qualifications	USDMF/-/-/-/-

Verapamil is a class IV antiarrhythmic drug and is a calcium antagonist, with almost the same selectivity for myocardium, sinoatrial node, atrioventricular node and blood vessels. Verapamil can block the influx of calcium ions, thereby reducing the autonomy of the sinoatrial and atrioventricular nodes, slowing down heart rate and conduction, weakening myocardial contractility, and reducing oxygen consumption; it also acts on vascular smooth muscle and dilates coronary arteries , Coronary blood flow and renal blood flow are significantly increased, which has a mild antihypertensive effect. As early as 2014, Anath Shalev's team had discovered the ability of verapamil to "completely reverse type 1 diabetes" in animal experiments and tried to conduct clinical trials. Since then, clinical results have shown that when patients take verapamil, β-cell function is preserved and more insulin can be secreted. This drug reduces the subject's need for insulin and is suitable for type 1 diabetes. Based on the above research results, the research team will also study the positive effects of verapamil on type 2 diabetes.

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