Zaleplon API

Name	Zaleplon
Chinese name	扎来普隆
Cas Number	151319-34-5
Source	India
Qualifications	/-/-/-/-

Zaleplon was developed by Wyeth-Ayerst. It is a non-benzodiazepine hypnotic. It is the first pyrazopyrimidine hypnotic and has significant clinical effects. Zaleplon produces central inhibitory effects through the GABA-benzodiazepine receptor complex, increases the opening frequency of chloride channels, causes hyperpolarization of nerve cell membranes, decreases excitability, and is highly selective for ω1 receptors, and for ω2- The affinity of the receptor is weak, but it does not bind to other neurotransmitters. Compared with traditional benzodiazepines, zaleplon has the following advantages: 1. Receptor binding tests show that zaleplon can selectively act on the ω1-receptors of the limbic system of the brain, so it is effective for memory The effect of Zaleplon is relatively weak; 2. Zaleplon is absorbed quickly after administration, it can help the patient fall asleep quickly, and then be metabolized quickly, but the patient can then sleep naturally without causing the next day’s Hangover; 3. Traditional benzodiazepines have long troubled patients with their dependence, sequelae effects and rebound insomnia. Zaleplon has less sequelae effects and rarely produces tolerance and Dependence, hardly cause rebound sleep disorder. According to data from the China Pharmaceutical Industry Information Center, the sales amount of sedative and hypnotics in sample hospitals in 2017 was approximately 972 million yuan.

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