Leflunomide API

Name	Leflunomide
Chinese name	来氟米特
Cas Number	75706-12-6
Source	India
Qualifications	USDMF/-/-/-/-

Leflunomide is an inhibitor of pyrimidine biosynthesis with antiproliferative activity and is approved for the treatment of rheumatoid arthritis in the United States. Lupus nephritis is a new indication for leflunomide, which was approved by the National Food and Drug Administration in 2009. Leflunomide mainly inhibits the synthesis of pyrimidine nucleotides by inhibiting the activity of dihydrolactate dehydrogenase that promotes pyrimidine synthesis during DNA synthesis, while inhibiting tyrosine phosphorylation and inhibiting interleukin (IL)-2 gene Start transcription, thereby inhibiting the production of (IL)-2, blocking the proliferation of activated lymphocytes and cell cycle progression, and reducing antibody production. X-ray results showed that the use of leflunomide significantly improved joint erosion and joint space narrowing, which is different from the existing anti-rheumatoid arthritis drugs including methotrexate and sulfasalazine , Is the first drug to show definite curative effect on objective indicators, and has the characteristics of fast onset, safe use, good tolerance, and long-term use by patients. According to the statistics of terminal sales of public medical institutions nationwide, the sales of flumeter in 2019 are about 800 million yuan.

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