Linaclotide API

Product Details

Name	Linaclotide
Chinese name	利那洛肽
Cas Number	851199-59-2
Synonyms	Linacllotide
Class	Active Pharmaceutical Ingredients (API) & Intermediates, API
Industry	Pharmaceutical
Molecular Formula	C59H79N15O21S6
Appearance	White Solid
Molecular Weight	1526.74
Source	India
Qualifications	-/-/-/-/-

Applications

Linaclotide is the first guanylate cyclase agonist (GCCA) drug. It was developed by Ironwood and was approved by the US FDA in August 2012. It is the only prescription drug approved for IBS-C in Europe. Linaclotide is a 14-amino acid peptide. After it binds to guanylate cyclase C located in the intestine, it increases the intracellular and extracellular cyclic guanosine phosphate (cGMP) concentration and the extracellular cGMP concentration increases. Reduce the sensitivity of the pain nerve and reduce intestinal pain. Compared with drugs that increase the secretion of intestinal juice, which passively acts through osmotic pressure, linaclotide works actively, actively pumping chloride ions into the intestinal lumen through the cystic fibrosis transmembrane conduction regulator protein channel, and then pumping water Actively pump into the intestinal cavity to improve the efficacy of the medicine. Linaclotide can increase the number of spontaneous bowel movements per week, improve stool characteristics, reduce stool strain, and the severity of constipation. Therefore, Linaclotide can be used as one of the first-line drugs for the treatment of functional constipation and has a broad market prospect. In 2018, global sales reached nearly RMB 5 billion.

Handle and Storage

Storage: Hygroscopic, Refrigerator, under inert atmosphere.

Our Services

Shipping

Regardless of the type of drug or the shape it takes, all products need to be handled with great care. We can offer you different shipping support from production to delivery, or anywhere in between. You can feel at ease knowing your products will be in good hands.

Company and Certificate

Guangzhou Tosun Pharmaceutical Ltd. is a high-teched enterprise with modern workshops and advanced production technology, located in Guangzhou, China and with nearly 200 staff members. The construction area is more than 3,000 square meters.

With a global network of procurement, R&D and marketing, it can quickly meet the needs of domestic and foreign pharmaceutical enterprises in products of R&D, production, and marketing sales. Now, about 40% of our products are exported to foreign markets, including Europe, India, Korea, Japan, US, and so on. We have established good cooperation with customers at home and abroad.

FAQ

Q1: How to know the exact price for this product?
A: Please provide your email address and detailed order information, then we can check and reply to you with the latest and exact price.

Q2: We have more questions, how to contact you?
A: We are a renowned and authentic manufacturer and supplier of Linaclotide in China. At Tosun Pharm, we have expertise in synthetic organic chemistry and pharmaceutical analysis and we provide cost-effective and accurate custom research services to the industry. Do you want a quotation or have a question about Linaclotide? Please Enquire Now! You can send inquiries through the inquiry form below or contact us by Email or Phone/ WhatsApp directly. We normally respond within 12 hours.
Phone/ WhatsApp: +86-189-2212-0635
Email: tonghuiyy218@upharm.cn

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