Agomelatine API

Name	Agomelatine
Chinese name	阿戈美拉汀
Cas Number	138112-76-2
Source	India
Qualifications	-/-/-/-/-

Agomelatine is a melatonin agonist developed by the French company Servier. It also antagonizes the 5HT2C receptor. It is the first melatonin antidepressant, which can effectively treat depression, improve sleep parameters and maintainability Features. The listing of agomelatine is a new breakthrough in the field of depression treatment. It is both a melatonin MT1/MT2 receptor agonist and a serotonin 2c (5-HT2C) receptor antagonist, through the synergy of the two , So that the disordered biological rhythms of depression patients return to normal, and produce antidepressant effects. Compared with selective serotonin reuptake inhibitors (SSRI) and serotonin-norepinephrine reuptake inhibitors (SNRI), agomelatine has significantly reduced adverse reactions and better patient compliance. Therefore, agomelatine is known as another "blockbuster" drug in the mental illness category. Agomelatine is better than sertraline in relieving symptoms of depression and anxiety for 6 weeks; compared with venlafaxine and paroxetine, agomelatine has less effect on sexual function. Agomelatine has been recommended as a first-line treatment for patients with depression with sleep disorders.

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