Leuprolide Acetate API

Name	Leuprolide Acetate
Chinese name	醋酸亮丙瑞林
Cas Number	74381-53-6
Source	Europe
Qualifications	USDMF/-/-/-/-

Leuprolide acetate is a synthetic nonapeptide, a highly active derivative of natural GnRH. It is a sustained-release preparation of leuprolide acetate microspheres jointly developed by Takeda of Japan and Abbvie of the United States. The US FDA approved it for marketing in 1989. Leuprolide acetate can regulate the secretory function of the pituitary gland, reduce the secretion of steroids in the ovary, force amenorrhea, shrink the endometrial lesions, and relieve symptoms; at the same time, it can reduce estrogen levels, inhibit estrogen-mediated inflammation, and relieve pain. Clinical trials have shown that the use of leuprolide acetate in the treatment of endometriosis (EMS) is more effective than ethinyl estradiol and cyproterone, and can reduce the levels of CA125 and E2, LH and FS in peripheral blood, and is well tolerated by patients . Compared with ethinyl estradiol and cyproterone, patients treated with leuprolide acetate performed better in terms of disease efficacy, menstrual re-fluid time, serum hormone indicators E2, LH and FSH. Leuprolide acetate achieved sales revenue of 735 million yuan in the first three quarters of 2019, a year-on-year increase of 24.67%, and the annual sales scale was close to 1 billion.

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