Dexzopiclone API

Name	Dexzopiclone
Chinese name	右佐匹克隆
Cas Number	138729-47-2
Source	India
Qualifications	USDMF/-/-/-/-

Ezopiclone is the right-handed isomer of zopiclone, developed by Sepracor. In 2004, the US FDA approved zopiclone for marketing. It has greater activity and lower toxicity than racemic zopiclone, thus driving the rapid growth of the market. Preclinical and clinical studies have shown that the affinity of this product for benzodiazepine receptors is 50 times that of levzopiclone. The residual effects and hangovers of dexzopiclone after taking the drug are less than those of benzodiazepines. There is no obvious drug resistance after long-term use. After long-term use, there is no obvious rebound phenomenon of dexzopiclone. Anxiety and difficulty falling asleep on the night of drug withdrawal, and symptoms of benzodiazepine withdrawal generally last until the third day of withdrawal, and rebound insomnia is obvious after most benzodiazepine drugs are stopped. The hospital purchase amount of Ezopiclone tablets in 2019 is RMB 302.45 million, and it is the TOP5 sedative and sleeping medicine in the hospital market. Ezopiclone has become a fast-growing variety after its market launch, bringing new options for differentiated medications, which will inevitably lead to a reshuffle of the sedative hypnotics market.

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