Linezolid API

Name	Linezolid
Chinese name	利奈唑胺
Cas Number	165800-03-3
Source	India/Taiwan
Qualifications	USDMF/-/-/-/-

Linezolid is a synthetic oxazolidinone antibiotic. The original research company is Pfizer. It was first approved by the US FDA in 2000 for the treatment of infections caused by gram-positive (G+) cocci, including methicillin-resistant golden yellow grapes. Suspected or confirmed hospital-acquired pneumonia (HAP), community-acquired (CAP), complicated skin or skin and soft tissue infections (SSTI), and vancomycin-resistant enterococcus (VRE) infections caused by bacteria (MRSA). Not only is its chemical structure different from other antibacterial drugs, but its mechanism of action also has new features. Because linezolid has a unique site and mode of action, it is not easy to cross-resistance with other antibacterial drugs that inhibit protein synthesis, and it is not easy to induce resistance in vitro, making it resistant to MRSA, VRE, and multi-drug resistant Streptococcus pneumoniae (MDRSP) etc. have strong antibacterial activity. Related guidelines suggest that linezolid is the first choice for the treatment of hospital-acquired pneumonia and soft tissue infections in MRSA. In 2019, the domestic market size of linezolid injection was 1.48 billion yuan.

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