Sirolimus API

Name	Sirolimus
Chinese name	西罗莫司
Cas Number	53123-88-9
Source	Europe
Qualifications	USDMF/-/-/-/-

Sirolomus, formerly known as Rapamycin Rapamune (RPM), is a lipophilic triene produced by Streptomyces hygroscopicus isolated from soil samples of Easier Island in the Pacific Ocean in 1975 by the Canadian Ayerst Laboratory. Macrolide antibiotics are immunosuppressive drugs. In 1989, Morris officially began to study RPM as a new and highly effective immunosuppressant for organ transplantation anti-rejection. It is found that the effective anti-proliferation effect of peripheral blood mononuclear cells is 50 to 500 times stronger than that of cyclosporine CA. Nephrotoxicity is lower than cyclosporine and tacrolimus (Tacrolimus). Combined with cyclosporine, it produces a synergistic effect. Sirolimus is a new type of potent immunosuppressant with less toxicity and potential, as a compound of ketene macrocyclic vinegar. It can prolong the survival period after transplantation and reduce the occurrence of acute rejection. The transplant provides a new alternative treatment method. Supply from well-known foreign manufacturers with guaranteed quality.

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