Tenofovir Propofol Fumarate API

Name	Tenofovir Propofol Fumarate
Chinese name	富马酸丙酚替诺福韦
Cas Number	1392275-56-7
Source	India
Qualifications	USDMF/-/-/-/-

Propofol fumarate tenofovir (TAF) is the second replacement for norfovir, and it is the first-line drug for the initial treatment of chronic hepatitis B recommended by the latest edition of the European Society for Liver Research Guidelines and the American Society for the Study of Liver Disease Guidelines. TAF was approved for marketing by the US FDA in 2016 and was approved by the European Medicines Agency on January 9, 2017. Tenofovir is a nucleotide analogue with good anti-HBV activity. However, it cannot pass through the human digestive tract barrier. TAF adds an amide bond to the structure of tenofovir to improve Intestinal absorption and bioavailability. Two global phase III, randomized double-blind, non-inferiority studies of TAF versus tenofovir disoproxil fumarate (TDF) show that TAF and TDF have similar antiviral effects, but have better kidney and bone safety it is good. Profol tenofovir and tenofovir disoproxil are the first-line drugs recommended by many guidelines, and propofol tenofovir is a newer product of tenofovir disoproxil with better clinical prospects.

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