Osimertinib Mesylate API

Name	Osimertinib mesylate
Chinese name	甲磺酸奥希替尼
Cas Number	1421373-65-0
Source	India
Qualifications	USDMF/-/-/-/-

Osimertinib is an irreversible third representative EGFR-TKI inhibitor, which can inhibit both EGFR sensitive mutations and EGFR-T790M resistant mutations, and metastasis to the central nervous system Has clinical effect. Osimertinib is a third-generation EGFR-TKI targeted drug, known as the "magic drug for lung cancer", and is the first-line drug recommended by relevant guidelines in many countries at home and abroad. Compared with the first and second generation EGFR-TKIs, their ability to penetrate the blood-brain barrier is stronger, and it has a good effect on patients with central nervous system metastasis. With the continuous improvement of osimertinib's status in NSCLC targeted therapy, it not only breaks the bottleneck of no drugs available for advanced NSCLC patients to the first and second generation EGFR-TKIs treatment resistance, but also improves the clinical practice of EGFR-positive advanced NSCLC patients The benefit threshold of first-line treatment. It has been approved for EGFR mutation-positive metastatic non-small cell lung cancer patients in 78 countries and regions around the world, including the European Union and the United States. In August 2019, osimertinib was approved for the first-line treatment of EGFR-positive advanced/metastatic NSCLC in adults in China, which is also a great news for Chinese patients.

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