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CAS:856676-23-8
Source:India
Qualifications:USDMF/CEP/-/-/-
Name | Fenofibrate choline |
---|---|
Chinese name | 非诺贝特胆碱 |
Cas Number | 856676-23-8 |
Source | India |
Qualifications | USDMF/CEP/-/-/- |
Fenofibrate Choline Sustained-Release Capsules are clofibrate derivatives of blood lipid regulators approved by the FDA in December 2008 by Abbott AbbVie. Norfibrate choline is a double salt formed by the combination of fenofibric acid and choline, the metabolite of fenofibrate in the body. Its solubility under alkaline conditions is significantly higher than that of fenofibrate and can reduce low-density lipoprotein (LDL) And triglyceride levels, increase high-density lipoprotein (HDL) levels, and can also be combined with statins to improve symptoms of hyperlipidemia. A large number of clinical experiments and drug studies have confirmed that the hydrophobicity of fenofibrate leads to its low bioavailability and is greatly affected by food. Contrary to fenofibrate, fenofibrate has higher levels in the small intestine. Solubility, therefore, increases the bioavailability of fenofibric acid, and the bioavailability is not affected by food. At the same time, the dosage is reduced, and the side effects are also reduced. AbbVenofibrate Choline Sustained Release Capsules had sales in 2015 of approximately US$163.1 million.
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