Zidovudine API

Name	Zidovudine
Chinese name	齐多夫定
Cas Number	30516-87-1
Source	India
Qualifications	USDMF/-/-/-/-

Zidovudine is a synthetic thymidine antiviral drug and is the first drug approved for the treatment of acquired immunodeficiency syndrome (AIDS). Zidovudine is a nucleoside reverse transcriptase inhibitor. Reverse transcriptase is an enzyme that plays a major role in the reverse transcription of HIV from mRNA to DNA. Zidovudine can be used as a substrate or competitive inhibitor of reverse transcriptase. And prevent the replication of the virus. Zidovudine was approved by the US FDA in March 1987. To this day, many drugs used to treat AIDS still contain zidovudine; it has become the most basic component of "cocktail" therapy because of its definite efficacy. Zidovudine can not only reduce the probability of opportunistic infections and neonatal occurrence, increase the number of T lymphocytes, but also cross the blood-brain barrier, achieve antiviral concentration in cerebrospinal fluid (CSF), reduce the amount of virus in CSF, and improve The neurophysiological function of patients with progressive encephalopathy can improve and reduce HIV-induced dementia, increase survival rate and improve quality of life; in addition, zidovudine can reduce the perinatal HIV mother-to-child transmission rate by nearly 70%. At present, China's anti-HIV drug market is in a state of vigorous growth, with annual sales increasing from 790 million yuan in 2013 to 2.02 billion yuan in 2018, with a compound annual growth rate of 20.65%

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