Tasmetron API

Name	Tasmetron
Chinese name	他司美琼
Cas Number	609799-22-6
Source	Europe
Qualifications	-/-/-/-/-

Tasmetron is a small molecule melatonin receptor agonist developed by Vanda Pharma in Maryland, USA. In January 2010, the FDA granted its orphan drug designation for the treatment of non-24 patients with total blindness. Hour sleep disorder, approved by the US FDA in January 2014, is the first mental disorder drug approved by the FDA for the treatment of this disease. Tasmetron is a selective MT1 and MT2 receptor agonist, which can simulate melatonin to activate the suprachiasmatic nucleus receptors, which can promote the organism to enter the night sleep state, thereby regulating non-24-hour wakefulness disorders. The evaluation results of Tasmetron on the Non-24 Clinical Response Scale (non-24CRS) and Clinical Global Impression Change Scale (CGI-C) were compared with placebo, and patients taking talsmetron increased their night sleep time ( Compared with the placebo group, it increased by 28 minutes), and the daytime sleep was reduced (compared to the placebo group by 27 minutes). Preclinical studies have shown that talsmetron has the properties of regulating the circadian cycle similar to melatonin, and has less vasoconstriction effect. Tasmetron has the advantages of small dosage, strong curative effect and good tolerance, and has good application prospects.

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