Norethindrone API

Name	Norethindrone
Chinese name	炔诺酮
Cas Number	68-22-4
Source	Europe
Qualifications	USDMF/-/-/-/-

Norethindrone is a derivative of 19-desmethyltestosterone. It is an oral effective progesterone. Its progestin effect is 5 times that of ethinylgestrol. It has mild androgenic and estrogenic activity. It is the first to be synthesized The oral high-potency progesterone. Norethindrone has an inhibitory effect on the secretion of hypothalamic luteinizing-releasing hormone (LHRH). By stimulating the anterior pituitary, it reduces the body's sensitivity to LHRH, thereby blocking the release of gonadotropins and producing an effect of inhibiting ovulation . Compared with ethinyl estradiol and cyproterone, norethindrone has a significant effect in the treatment of anovulatory dysfunctional uterine bleeding, not only can effectively improve the patient's hormone level, but also greatly reduce the occurrence of complications, and is more clinically safe. high. The US FDA approved Oriahnn in May 2020: a new drug combination containing norethindrone for the treatment of heavy menstrual bleeding caused by uterine fibroids in premenopausal women.

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