Topotecan Hydrochloride API

Name	Topotecan Hydrochloride
Chinese name	盐酸拓扑替康
Cas Number	119413-54-6
Source	India
Qualifications	USDMF/-/-/-/-

Topotecan hydrochloride is a new semi-synthetic anti-tumor drug launched by Smithkline Beecham Pharmaceuticals in the United States in 1996. It is also the world’s first anti-tumor drug that acts on topoisomerase I. Its mechanism of action is similar to other camptothecins. A specific topoisomerase I inhibitor. Topotecan's broad-spectrum anti-cancer activity is higher than camptothecin, and it has significant curative effect on human colon cancer, ovarian cancer and small cell lung cancer. Because of its better anti-tumor activity and lower toxicity, it has been widely concerned. It has been approved by the FDA for the treatment of malignant ovarian cancer and recurrent small cell lung cancer that have failed chemotherapy regimens containing cisplatin or paclitaxel. Clinical studies have proved that Topotere Kang has a good therapeutic effect on epithelial ovarian cancer, especially for patients with advanced epithelial ovarian cancer whose condition has deteriorated after first-line treatment with platinum-containing drugs. It has been reported that the oxaliplatin combined with topotecan hydrochloride regimen is superior to oxaliplatin single-agent regimen in terms of efficacy. Topotecan hydrochloride and irinotecan monotherapy have no difference in short-term and long-term efficacy in the treatment of small cell lung cancer in the elderly. Topotecan has milder gastrointestinal adverse reactions than irinotecan, and topotecan hydrochloride has better safety . However, like other camptothecin drugs, the lactone ring in the structure of topotecan is prone to hydrolysis to convert to the carboxylate form under physiological conditions, thereby losing its activity. In order to solve this problem, China is currently developing lipids. This new dosage form of plastid injection.

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