Polymyxin E Sodium Methanesulfonate API

Name	Polymyxin E sodium methanesulfonate
Chinese name	多黏菌素E甲磺酸钠
Cas Number	8068-28-8
Source	India
Qualifications	-/-/-/-/-

Polymyxin E sodium methanesulfonate was first developed by ParSterile Products. It is a peptide antibiotic and was included in the priority review list by the Drug Evaluation Center of the State Drug Administration. Polymyxin E sodium methanesulfonate is a group of basic polypeptide antibiotics produced by Bacillus polymyxa. It has a bactericidal effect on gram-negative bacteria, mainly by changing the permeability of the bacterial cell membrane. Polymyxin E sodium methanesulfonate is currently the drug of choice for the treatment of infections caused by multi-drug-resistant Pseudomonas aeruginosa and other gram-negative bacteria. The drug resistance rate is low (less than 5%), and it is combined with other antibiotics or antibacterial The drug does not produce cross-resistance, and it is a super antibiotic urgently needed by domestic patients with acute and severe illness. The reason why polymyxin E sodium methanesulfonate can be used as an injection is that its toxicity is significantly lower than that of polymyxin E sulfate, and the LD50 is reduced by more than 50 times. Due to the strong antibacterial activity of polymyxin E methanesulfonate against drug-resistant bacteria, and the increasing resistance of drugs such as hydrocarbons, the clinical demand will continue to increase in the future.

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