Epipiprazole API

Name	Epipiprazole
Chinese name	依匹哌唑
Cas Number	913611-97-9
Source	India
Qualifications	USDMF/-/-/-/-

Epizolide is the first dopamine D2, 5-HT1A receptor agonist and 5-HT2A receptor antagonist compound jointly developed by Danish Lingbei Pharmaceutical and Otsuka Corporation of Japan. It was approved by the US FDA in August 2015. Listed. Epizolide works by partially activating serotonin 5-HTIA receptors and dopamine D2 receptors, and blocking serotonin 5-HT2A receptors. Compared with aripiprazole, epizolide has increased affinity for 5-HT receptors, decreased activity on D2 receptors, better tolerance, and lower incidence of side effects of akathisia. The negative symptoms of schizophrenia and the efficacy of cognitive function have a better trend. Among various second-generation antipsychotic drugs used for antidepressant synergistic treatment, the rate of discontinuation of epizolide due to adverse events was 2.6%, which is much lower than that of quetiapine, risperidone and olanzapine. Fluoxetine mixture. Epipiprazole is a clinically significant multi-target antipsychotic drug with a good development prospect. In 2019, sales of Epizolide were US$1.43 billion.

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