Tamsulosin Hydrochloride API

Name	Tamsulosin Hydrochloride
Chinese name	盐酸坦索罗辛
Cas Number	80223-99-0
Source	Taiwan
Qualifications	USDMF/CEP/-/-/-

Tamsulosin hydrochloride is a third-generation super-selective long-acting α1 inhibitor. It was successfully developed by Yamanouchi Pharmaceutical Co., Ltd., and was approved by the FDA for marketing in July 1992. Tamsulosin hydrochloride is a subtype highly selective α1 receptor blocker, which is specially developed for the treatment of BPH. It can block α1A receptors in the prostate and α1A and α1D receptors in the bladder. The smooth muscle of the above-mentioned parts relaxes, reduces the pressure of the prostate urethra, thereby improving the patient's urination function and clinical symptoms. Unlike other α-1 blockers such as doxazosin and terazosin, tamsulosin hydrochloride has a higher selectivity for prostate smooth muscle and a weak effect on blood vessels, thus greatly reducing such things as low erection The occurrence of side effects such as blood pressure. Compared with finasteride, tamsulosin hydrochloride can improve symptoms within a short time after treatment; because tamsulosin hydrochloride has a higher selectivity for prostate smooth muscle and a weak effect on blood vessels, it greatly reduces Orthostatic hypotension and other side effects occur, so tamsulosin hydrochloride has a wider application prospect. In 2018, the corresponding terminal market sales of tamsulosin hydrochloride sustained-release capsules were approximately 1.6 billion yuan.

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