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CAS:380917-97-5
Source:India
Qualifications:USDMF/-/-/-/-
Name | Perampanel |
---|---|
Chinese name | 吡仑帕奈 |
Cas Number | 380917-97-5 |
Synonyms | 3-(2-Cyanophenyl)-1-phenyl-5-(2-pyridyl)-1,2-dihydropyridin-2-one |
Class | Active Pharmaceutical Ingredients (API) & Intermediates, API |
Industry | Pharmaceutical |
Molecular Formula | C23H15N3O |
Appearance | Powder |
Molecular Weight | 349.38 |
Source | India |
Qualifications | USDMF/-/-/-/- |
Originally researched by Eisai, Perampanel was approved by the FDA for the first time in the United States in 2012 for the adjuvant treatment of partial seizures in patients with epilepsy over 12 years of age, regardless of whether the patient is accompanied by a secondary full-blown seizure, this is the first FDA approval Anti-epileptic drugs with this mechanism of action. On October 15, 2019, Eisai announced that the National Medical Products Administration (NMPA) has approved its new anti-epileptic drug perampanel. So far, perampanel has been approved in more than 55 countries around the world. Perampanel is a pioneering anti-epileptic tablet developed by the Tsukuba Research Center and is taken orally once a day. The drug is a highly selective, non-competitive AMPA receptor antagonist. AMPA receptor is an important subtype of ionotropic glutamate receptors, which mainly mediates excitatory synapses in the central nervous system. Transmission effect: Perampanel can inhibit the glutamate activity of AMPA receptors in postsynaptic membrane by targeting to reduce the excessive excitement of neurons related to epileptic seizures, thereby achieving the purpose of preventing and treating epilepsy diseases.
Storage: N/A
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