Paliperidone API

Name	Paliperidone
Chinese name	帕利哌酮
Cas Number	199739-10-1
Source	India/Malta
Qualifications	USDMF/-/-/-/-

Paliperidone is the first new drug approved for the treatment of schizophrenia since 2003, and is the main metabolite of risperidone. The mechanism of action of paliperidone is mediated by the combined action of central dopamine 2 (D2) receptors and 5-hydroxytryptamine (5HT2A) receptors. In addition, paliperidone is also α1 and α2 adrenergic receptors and Antagonist of H1 histamine receptor. In addition, paliperidone does not cause extensive metabolism in the liver, and is secreted in large quantities through the kidneys without changes. It has the characteristics of side effects such as involuntary movements or tremors that are unique to atypical schizophrenia drugs. It is superior to the traditional drug olanzapine in terms of drug resistance and drug resistance. At the same time, there are fewer metabolic disorders, so it has good application prospects.

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